a tool for identifying drug-targetable redox-active disulphides

Secreted effector protein SptP

Intermolecular

Cysteine 250 and cysteine 18 of Ras-related C3 botulinum toxin substrate 1

A redox-regulated disulphide may form between cysteine 250 of Secreted effector protein SptP and cysteine 18 of Ras-related C3 botulinum toxin substrate 1. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

36

PDB code

Structure name

crystal structure of the salmonella tyrosine phosphatase and gtpase activating protein sptp bound to rac1

Structure deposition date

2000-10-28

Thiol separation (Å)

10

Half-sphere exposure sum ?

66

Minimum pK_a ?

10

% buried

94

Peptide A name

Secreted effector protein SptP

Peptide B name

Ras-related C3 botulinum toxin substrate 1

Peptide A accession

Peptide B accession

Peptide A residue number

250

Peptide B residue number

18

Ligandability

Cysteine 250 of Secreted effector protein SptP

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 18 of Ras-related C3 botulinum toxin substrate 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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